Homology Model of Human FIXa


All structural analysis of the mutations presented within this database uses the homology model of FIXa (FIXa_HUMAN.pdb) that was generated by us from the experimental structures available for the 4 domains individually.

The PDB codes of the experimental structures for these 4 human domains are: Gla domain (PDB code: 1CFI), the EGF1 domain (PDB code: 1EDM) and the EGF2-SP domain pair (PDB code: 3KCG).


Experimental Structures available for HUMAN Coagulation Factor IX


 PDB  

 Method  

 Description 

 Resolution 

 Chain 

 Position 

 PDBsum 

1CFH NMR structure of the metal-free gamma-carboxyglutamic acid-rich membrane binding region of factor ix by two-dimensional nmr spectroscopy - A 47-93 >>
1CFI NMR nmr structure of calcium ion-bound gamma-carboxy-glutamic acid-rich domain of factor ix - A 47-93 >>
1EDM X-ray epidermal growth factor-like domain from human factor ix 1.50 B/C 92-130 >>
1IXA NMR the three-dimensional structure of the first egf-like module of human factor ix: comparison with egf and tgf-a - A 92-130 >>
1MGX NMR coagulation factor, mg(ii), nmr, 7 structures (backbone atoms only) - A 47-93 >>
1NL0 X-ray crystal structure of human factor ix gla domain in complex of an inhibitory antibody, 10c12 2.20 G 47-91 >>
1RFN X-ray human coagulation factor ixa in complex with p-amino benzamidine 2.80 A 227-461 >>
1RFN X-ray human coagulation factor ixa in complex with p-amino benzamidine 2.80 B 133-188 >>
2WPH X-ray factor ixa superactive triple mutant 1.50 E 133-191 >>
2WPH X-ray factor ixa superactive triple mutant 1.50 S 227-461 >>
2WPI X-ray factor ixa superactive double mutant 1.99 E 133-191 >>
2WPI X-ray factor ixa superactive double mutant 1.99 S 227-461 >>
2WPJ X-ray factor ixa superactive triple mutant, nacl-soaked 1.60 E 133-191 >>
2WPJ X-ray factor ixa superactive triple mutant, nacl-soaked 1.60 S 227-461 >>
2WPK X-ray factor ixa superactive triple mutant, ethylene glycol-soaked 2.21 E 133-191 >>
2WPK X-ray factor ixa superactive triple mutant, ethylene glycol-soaked 2.21 S 227-461 >>
2WPL X-ray factor ixa superactive triple mutant, edta-soaked 1.82 E 133-191 >>
2WPL X-ray factor ixa superactive triple mutant, edta-soaked 1.82 S 227-461 >>
2WPM X-ray factor ixa superactive mutant, egr-cmk inhibited 2.00 E 133-191 >>
2WPM X-ray factor ixa superactive mutant, egr-cmk inhibited 2.00 S 227-461 >>
3KCG X-ray crystal structure of the antithrombin-factor ixa-pentasaccharide complex 1.70 H 227-461 >>
3KCG X-ray crystal structure of the antithrombin-factor ixa-pentasaccharide complex 1.70 L 131-188 >>
3LC3 X-ray benzothiophene inhibitors of factor ixa 1.90 A/C 227-461 >>
3LC3 X-ray benzothiophene inhibitors of factor ixa 1.90 B/D 133-188 >>
3LC5 X-ray selective benzothiophine inhibitors of factor ixa 2.62 A 227-461 >>
3LC5 X-ray selective benzothiophine inhibitors of factor ixa 2.62 B 133-188 >>


Experimental Structures available for porcine Coagulation Factor IX


 PDB  

 Method  

 Description 

 Resolution 

 Chain 

 Position 

 PDBsum 

1PFX X-ray x-ray structure of clotting factor ixa: active site and module structure related to xase activity and hemophilia b. 3.00 L 1-146 >>
1PFX X-ray x-ray structure of clotting factor ixa: active site and module structure related to xase activity and hemophilia b. 3.00 C 183-410 >>
1X7A X-ray sar and factor ixa crystal structure of a dual inhibitor of factors ixa and xa. 2.90 L 1-146 >>
1X7A X-ray sar and factor ixa crystal structure of a dual inhibitor of factors ixa and xa. 2.90 C 183-410 >>


Experimental Structures available for bovine Coagulation Factor IX


 PDB  

 Method  

 Description 

 Resolution 

 Chain 

 Position 

 PDBsum 

1J34 X-ray crystal structure of mg2+- and ca2+-bound gla domain of factor ix complexed with binding protein. 1.55 C 1-46 >>
1J35 X-ray crystal structure of mg2+- and ca2+-bound gla domain of factor ix complexed with binding protein. 1.80 C 1-46 >>